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* [[Tadalafil|Tadalafil (Cialis)]] | * [[Tadalafil|Tadalafil (Cialis)]] | ||
* [[Vardenafil|Vardenafil (Levitra, Staxyn, Vivanza)]] | * [[Vardenafil|Vardenafil (Levitra, Staxyn, Vivanza)]] | ||
== Risks == | |||
In some individuals or in high doses, poppers can cause vomiting, methemoglobinemia, hypoxemia, reduced oxygen level in the blood, and unconsciousness<ref name=":0">{{Cite journal |last=Barry |first=Katherine |last2=McAteer |first2=Kristina E. |date=2023-04-03 |title=Syncope and Methemoglobinemia Preceded by Amyl Nitrite 'Popper' Inhalation |url=https://pubmed.ncbi.nlm.nih.gov/36989098/ |journal=Rhode Island Medical Journal (2013) |volume=106 |issue=3 |pages=49–51 |issn=2327-2228 |pmid=36989098}}</ref> which can persist for an extended time even after popper use is stopped.<ref name=":1">{{Cite journal |last=Olazagasti |first=Coral |last2=Paralkar |first2=Janvi |last3=Vishnevetsky |first3=Michael |last4=Chakravarti |first4=Aloke |last5=Sulica |first5=Roxana |last6=Favila |first6=Kristine |date=2016-10 |title=Poppers Not Only Make You High: A Rare Case of Amyl Nitrate-Induced Hypoxia |url=https://doi.org/10.1016/j.chest.2016.08.1216 |journal=Chest |volume=150 |issue=4 |pages=1108A |doi=10.1016/j.chest.2016.08.1216 |issn=0012-3692}}</ref> | |||
Poppers can cause chemical burns if the liquid becomes exposed to skin or sinuses. | |||
== Risk mitigation == | |||
Cease poppers usage if blood oxygen levels become lowered. Pale or blue skin or lips, headache or a pulse oximeter can all be used to identifiy low blood oxygen levels. If you don't recover, then seek medical help. | |||
Avoid spilling poppers which can expose you to higher concentrations over a period of time than otherwise intended. | |||
== Known incidents == | |||
=== Medical case reports === | |||
* 23yr old male in the ER with hypoxemia, methemoglobinemia, and syncope (2023)<ref name=":0" /> | |||
* 39yr old male in the ER with hypoxemia and methemoglobinemia (2012)<ref>{{Cite journal |last=McCabe |first=Aileen |last2=McCann |first2=Brendan |last3=Kelly |first3=Paul |date=2012-11-21 |title=Pop goes the O2: a case of popper-induced methaemoglobinamia |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543718/ |journal=BMJ Case Reports |volume=2012 |pages=bcr2012007176 |doi=10.1136/bcr-2012-007176 |issn=1757-790X |pmc=4543718 |pmid=23175012}}</ref> | |||
* 55yr old male in the ER with hypoxemia and methemoglobinemia for over a day (2016)<ref name=":1" /> | |||
* 44yr old male in the ER with hypoxemia, methemoglobinemia, unresponsive, stopped heart (1995)<ref>{{Cite journal |last=Edwards |first=R J |last2=Ujma |first2=J |date=1995-06 |title=Extreme methaemoglobinaemia secondary to recreational use of amyl nitrite. |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1342554/ |journal=Journal of Accident & Emergency Medicine |volume=12 |issue=2 |pages=138–142 |issn=1351-0622 |pmc=1342554 |pmid=7582412}}</ref> | |||
* 34yr old male in the ER with hypoxemia and methemoglobinemia for 4 days (2012)<ref>{{Cite journal |last=Wong |first=Anselm |last2=Koutsogiannis |first2=Zeff |last3=Greene |first3=Shaun |last4=McIntyre |first4=Shona |date=2013-03-01 |title=A case of hemolysis and methemoglobinemia following amyl nitrite use in an individual with G6PD deficiency |url=https://www.sciencedirect.com/science/article/pii/S2211558713000071 |journal=Journal of Acute Medicine |volume=3 |issue=1 |pages=23–25 |doi=10.1016/j.jacme.2012.12.005 |issn=2211-5587}}</ref> | |||
== External links == | == External links == |