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GHB: Difference between revisions
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{{Infobox drug | {{Infobox drug | ||
| other_names = | | other_names = gamma-hydroxybutyric acid | ||
GBL (gamma-butyrolactone) | |||
BDO (1,4-butanediol) | |||
| image_file = | | image_file = | ||
| image_caption = | | image_caption = | ||
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}} | }} | ||
''' | '''GHB''' (also known as '''''gamma''-hydroxybutyric acid'''), is a depressant used recreationally for its alcohol-like effects. Related drugs such as '''GBL''' (''gamma''-butyrolactone) and '''BDO''' (1,4-butanediol) are pro-drugs of GHB (meaning that the body's metabolism turns them into actual GHB). These drugs produce very similar effects to GHB, but have important differences in their dosing, time to onset of effects, and duration of action. | ||
== Background<!-- Provide background information for this drug. --> == | == Background<!-- Provide background information for this drug. --> == | ||
=== Medical uses === | === Medical uses === | ||
In the United States, GHB is a schedule I controlled substance (defined as having no current accepted medical use). However, GHB does have FDA | In the United States, GHB is a schedule I controlled substance (defined as having no current accepted medical use). However, GHB does have FDA approval as an orphan drug to treat narcolepsy with a specific formulation which is classified as schedule III.<ref>{{Cite web |title= |url=https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=530216}}</ref> | ||
GHB was previously used as a general anesthetic, but was abandoned due to a high incidence of myoclonic seizures and vomiting.<ref>{{Cite journal |last=Kam |first=P. C. |last2=Yoong |first2=F. F. |date=1998-12 |title=Gamma-hydroxybutyric acid: an emerging recreational drug |url=https://pubmed.ncbi.nlm.nih.gov/10193223 |journal=Anaesthesia |volume=53 |issue=12 |pages=1195–1198 |doi=10.1046/j.1365-2044.1998.00603.x |issn=0003-2409 |pmid=10193223}}</ref> These side effects correlate closely to common signs of GHB overdose when used recreationally. | GHB was previously used as a general anesthetic, but was abandoned due to a high incidence of myoclonic seizures and vomiting.<ref>{{Cite journal |last=Kam |first=P. C. |last2=Yoong |first2=F. F. |date=1998-12 |title=Gamma-hydroxybutyric acid: an emerging recreational drug |url=https://pubmed.ncbi.nlm.nih.gov/10193223 |journal=Anaesthesia |volume=53 |issue=12 |pages=1195–1198 |doi=10.1046/j.1365-2044.1998.00603.x |issn=0003-2409 |pmid=10193223}}</ref> These side effects correlate closely to common signs of GHB overdose when used recreationally. | ||